Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

Abstract Background Aging significantly elevates the risk of developing neurodegenerative diseases.Neuroinflammation is a universal hallmark of neurodegeneration as well as normal brain aging.Which branches of age-related neuroinflammation, and how they precondition the brain toward pathological progression, remain ill-understood.The presence of el

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The dCas9-based genome editing in Plasmodium yoelii

ABSTRACTGenetic editing is a powerful tool for functional characterization of genes in various organisms.With its simplicity and specificity, the CRISPR-Cas9 technology has become a popular editing tool, which introduces site-specific DNA double-strand breaks (DSBs), and then leverages the endogenous repair pathway for DSB repair via homology-direc

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